Structure of PDB 9eud Chain B

Receptor sequence
>9eudB (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEIAHLLIKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKGE
3D structure
PDB9eud 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile.
ChainB
Resolution2.022 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H7G B Y57 D68 F77 Q85 V86 W90 Y113 F130 Y45 D56 F65 Q73 V74 W78 Y101 F118
External links
PDB RCSB:9eud, PDBe:9eud, PDBj:9eud
PDBsum9eud
PubMed38818693
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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