Structure of PDB 9euc Chain B

Receptor sequence
>9eucB (length=121) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
KFDSSHPFVFSLGKGQVIKAWDIGVATMKKGEIAHLLIKPEYAYGSAGSL
PKIPSNATLFFEIELLDFKGE
3D structure
PDB9euc 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H7F B Y57 D68 F77 V86 I87 W90 Y113 I122 F130 Y45 D53 F58 V67 I68 W71 Y94 I103 F111
External links
PDB RCSB:9euc, PDBe:9euc, PDBj:9euc
PDBsum9euc
PubMed38818693
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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