Structure of PDB 9cd7 Chain B

Receptor sequence
>9cd7B (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAV
KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEY
AAKGNLREFLRARRPPQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR
NVLVTEDNVMKIADFGLARDVHNLDYYKLPVKWMAPEALFDRVYTHQSDV
WSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIM
RECWHAAPSQRPTFKQLVEDLDRVLTVT
3D structure
PDB9cd7 Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.
ChainB
Resolution2.53 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AV2 B L478 G479 E480 V486 A506 Y557 A558 N562 R621 L624 L21 G22 E23 V29 A49 Y100 A101 N105 R150 L153
External links
PDB RCSB:9cd7, PDBe:9cd7, PDBj:9cd7
PDBsum9cd7
PubMed39258897
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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