Structure of PDB 9cd5 Chain B

Receptor sequence
>9cd5B (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
VSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVT
KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYV
IVEYASKGNLREYLQARRPEQLSSKDLVSCAYQVARGMEYLASKKCIHRD
LAARNVLVTEDNVMKIADFGLARDIIDYYKKTTNGRLPVKWMAPEALFDR
IYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC
TNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ
3D structure
PDB9cd5 Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.
ChainB
Resolution2.939 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AV2 B L484 V492 A512 Y563 A564 N568 R627 L630 D641 L25 V33 A53 Y104 A105 N109 R154 L157 D168
External links
PDB RCSB:9cd5, PDBe:9cd5, PDBj:9cd5
PDBsum9cd5
PubMed39258897
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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