Structure of PDB 9bc7 Chain B

Receptor sequence
>9bc7B (length=506) Species: 9606 (Homo sapiens) [Search protein sequence]
MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRF
YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMN
FRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGR
ALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLI
GMLLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKA
MSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDS
SRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNE
LNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYI
IREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTAS
VRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILL
QKFQKD
3D structure
PDB9bc7 Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
ChainB
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP B G539 I541 C542 R549 T550 G437 I439 C440 R447 T448
External links
PDB RCSB:9bc7, PDBe:9bc7, PDBj:9bc7
PDBsum9bc7
PubMed39085604
UniProtO60741|HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Gene Name=HCN1)

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