Structure of PDB 8zgs Chain B

Receptor sequence
>8zgsB (length=158) Species: 10116 (Rattus norvegicus) [Search protein sequence]
WQSFLKKELEFLGVTQVLVGLICLCFGTVVCSTLQTSDFDDEVLLLYRAG
YPFWGAVLFVLSGFLSIMSERKNTLYLVRGSLGANIVSSIAAGLGIAILI
LNLSNNSAYMNYCKDITEDDGCFVTSFITELVLMLLFLTILAFCSAVLLI
IYRIGQEF
3D structure
PDB8zgs Structure of the ige-fc bound to its high affinity receptor fc(epsilon)ri state2
ChainB
Resolution3.04 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 B L67 L70 L18 L21
Gene Ontology
Molecular Function
GO:0019863 IgE binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0043306 positive regulation of mast cell degranulation
GO:0051279 regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0032998 Fc-epsilon receptor I complex

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Cellular Component
External links
PDB RCSB:8zgs, PDBe:8zgs, PDBj:8zgs
PDBsum8zgs
PubMed39169187
UniProtP13386|FCERB_RAT High affinity immunoglobulin epsilon receptor subunit beta (Gene Name=Ms4a2)

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