Structure of PDB 8zfr Chain B

Receptor sequence
>8zfrB (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTEHPLLQEI
YK
3D structure
PDB8zfr Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
ChainB
Resolution2.73 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EEY B F282 C285 Q286 I326 Y327 L330 F363 F65 C68 Q69 I109 Y110 L113 F146
BS02 NZA B F264 I281 F282 G284 R288 L330 I341 S342 M348 M364 F58 I64 F65 G67 R71 L113 I124 S125 M131 M147
External links
PDB RCSB:8zfr, PDBe:8zfr, PDBj:8zfr
PDBsum8zfr
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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