Structure of PDB 8zfo Chain B

Receptor sequence
>8zfoB (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTSPFVIYDMNSLMMGEDEV
AIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIY
TMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL
ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPE
SSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTHPLLQEIY
3D structure
PDB8zfo Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
ChainB
Resolution3.15 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GW9 B F282 C285 Q286 I326 Y327 L330 F363 K367 H449 F55 C58 Q59 I99 Y100 L103 F136 K140 H222
BS02 NZA B I281 G284 C285 R288 L330 I341 S342 M348 M364 I54 G57 C58 R61 L103 I114 S115 M121 M137
External links
PDB RCSB:8zfo, PDBe:8zfo, PDBj:8zfo
PDBsum8zfo
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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