Structure of PDB 8z8n Chain B

Receptor sequence
>8z8nB (length=656) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence]
MNLFTPLSEINPTTTQELLYAYTGPAPVAYGTRTRAVLENIIRPYQYFYK
EPNVQRALDIKTGCKEPEDINVEGPSSGFHTASVLKLADNFFRKYRPAME
KLKYWILVKLPKLKYAELSKGRQTYSFIHKRNLPAPIALEETVEFLEQNL
RRKIGPTLLSYCQAIADVMELDETTYEGTYTIKFSREELWDQMRTLNTMW
KHLERGRLNRRTIATPSMLIRGFVKIVEDAAKEILENVPTSGVPVGGEEK
LAKLASKQTFHTAVTGELSGDQEKFNECLDPDAMRLMWTVFLRKLGCPDW
IMELFNIPFMVFKSKLADMGEGLVYTKGKLTDRKPLGEMPSEFDDLVRNV
VGNSISCRLGMFMGMYNLTSTLLALISIEREELTGSHVESSDDFIHFFNC
KTHEEMFKQAETLRLTLKLVGINMSPSKCILISPAGIGEFNSKFHHRDFV
GNVATELPALVPNGTNPMTDLAMGLNVIKHSVNTGQMNLCTGALAMRIFN
HAYKYAYMALGVTRRTRFMEENAITPLLTNQGASPVHSFSTMHLDEVALR
RHLGLLDEETLRRILNPNNPVTQIMEDYSVPSCFKYTLSRHKALLNKEER
YQRVTSIINKLFPEVLIQEASAPGTVRESLKRRLELVVERSDLDEERKKR
ILSRIF
3D structure
PDB8z8n Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
ChainB
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Y30 G31 T32 R35 R363 Y30 G31 T32 R35 R333
BS02 rna B H531 Y535 G541 V542 H501 Y505 G511 V512
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8z8n, PDBe:8z8n, PDBj:8z8n
PDBsum8z8n
PubMed38816392
UniProtO41353|RDRP_THOGV RNA-directed RNA polymerase catalytic subunit (Gene Name=Segment)

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