Structure of PDB 8z5l Chain B

Receptor sequence
>8z5lB (length=227) Species: 615 (Serratia marcescens) [Search protein sequence]
GPGVGESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYL
IDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPT
YASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVV
WLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPS
HSEVGDASLLKLTLEQAVKGLNESKKP
3D structure
PDB8z5l Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis.
ChainB
Resolution2.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN B H81 H83 H143 H81 H83 H143
BS02 ZN B D85 H201 D85 H201
BS03 ZN B H38 E203 H38 E203
BS04 A1LXO B E27 V29 W32 V35 F55 H81 D85 H143 C162 K165 N171 H201 E27 V29 W32 V35 F55 H81 D85 H143 C162 K165 N171 H201
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8z5l, PDBe:8z5l, PDBj:8z5l
PDBsum8z5l
PubMed38690676
UniProtP52699|BLAB_SERMA Metallo-beta-lactamase type 2

[Back to BioLiP]