Structure of PDB 8z3s Chain B

Receptor sequence
>8z3sB (length=900) Species: 9606 (Homo sapiens) [Search protein sequence]
GQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVGWMTSVKDWAGVMIS
AQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAF
NVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGL
RFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLV
ENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVF
FILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESV
SNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVL
NPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRI
ITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTM
LANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCEL
CFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVK
RAFFYCKACNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVC
IFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHN
FPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECIL
ASLNIKSMQFDDSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLT
QPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEE
NALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKT
YNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFD
3D structure
PDB8z3s Activation mechanism and novel binding site of the BKCa channel activator CTIBD
ChainB
Resolution3.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1L04 B W203 S259 P262 W147 S203 P206
BS02 CA B D367 R514 S533 E535 S600 D311 R458 S477 E479 S544
BS03 CA B Q947 D950 D953 D955 Q733 D736 D739 D741
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
GO:0046872 metal ion binding
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0001666 response to hypoxia
GO:0006813 potassium ion transport
GO:0006970 response to osmotic stress
GO:0030007 intracellular potassium ion homeostasis
GO:0034465 response to carbon monoxide
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0045794 negative regulation of cell volume
GO:0051592 response to calcium ion
GO:0060073 micturition
GO:0060083 smooth muscle contraction involved in micturition
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0034702 monoatomic ion channel complex
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8z3s, PDBe:8z3s, PDBj:8z3s
PDBsum8z3s
PubMed39089879
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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