Structure of PDB 8yp3 Chain B

Receptor sequence

>8yp3B (length=454) Species: 7108 (Spodoptera frugiperda) [Search protein sequence]

HHMSYDSIFENLNSHGQGHLLKYWPDLSEKERAQLLNDLKKIDFAEVNEL
EDLKPIPDSHYEAVPNLSNEKILEYENIGLREISDGKVGVLLLAGGQATR
LGFGHPKGMYDVGLPSRKTLFQIQAERIVRVQQMAAEKYGKEGKITWYIM
TSEHTRGPTADYFRSHNYFGLNEEDIVYFEQGTLPCFDFEGKIFLDEKYH
VSSAPDGNGGLYRALKNQGVLDDIAKRGVEHLHAHSVDNILIKVADPVFI
GYCKSKNADCAAKVVQKSTPSEAVGVVCRVNGHYKVVEYSELTDEAAESR
TLTFSAGNICNHYFSSEFLTKICNKLKLHVAKKKIPYVDHEGVRQKPTEP
NGIKMEKFIFDVFEFAENFICLEVARDVEFSALKNNDAAKKDCPSTARED
LLRLHRKYVREAGGIVEDNIDVEISPLLSYGGENLTDLVSGEVFTISPYH
LKSM

3D structure

PDB

8yp3 Structure and Inhibition of Insect UDP- N -acetylglucosamine Pyrophosphorylase: A Key Enzyme in the Hexosamine Biosynthesis Pathway.

Chain

Resolution

2.12 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UD1	B	L113 G115 G116 Q201 G227 N228 S256 V257 V294 G295 E308 Y309 N332 F387 F407 K411	L93 G95 G96 Q181 G207 N208 S236 V237 V274 G275 E288 Y289 N308 F360 F380 K384
BS02	MG	B	N332 C334 H336	N308 C310 H312

External links

PDB	RCSB:8yp3, PDBe:8yp3, PDBj:8yp3
PDBsum	8yp3
PubMed	39039661
UniProt	A0A2H1VI03

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