Structure of PDB 8yki Chain B

Receptor sequence
>8ykiB (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
GSSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKPNRVTK
VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVI
VEYASKGNLREYLQARLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN
VLVTEDNVMKIADFGLLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT
LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP
TFKQLVEDLDRIVALT
3D structure
PDB8yki Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion.
ChainB
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LY1 B V492 A512 K514 E531 V561 A564 L630 D641 F642 V34 A52 K54 E71 V101 A104 L152 D163 F164
External links
PDB RCSB:8yki, PDBe:8yki, PDBj:8yki
PDBsum8yki
PubMed38821585
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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