Structure of PDB 8yf1 Chain B

Receptor sequence
>8yf1B (length=567) Species: 9606 (Homo sapiens) [Search protein sequence]
PGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVE
VFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRR
QCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSE
FLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHS
WRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNM
RAKGHPERVFSVTHIKTIHQEDTWYQRWGVRALSLGGQVWGNFLSCFGPE
YRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERV
EHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSS
NTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGE
GAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFL
SFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNAL
CKLAAVLGISIFTSFVG
3D structure
PDB8yf1 Cryo-EM structure of human SV2A in complex with Brivaracetam
ChainB
Resolution3.38 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VLX B I273 F277 C297 W300 I663 W666 N667 I141 F145 C165 W168 I521 W524 N525
Gene Ontology
Molecular Function
GO:0019901 protein kinase binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0006874 intracellular calcium ion homeostasis
GO:0014052 regulation of gamma-aminobutyric acid secretion
GO:0016082 synaptic vesicle priming
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0030425 dendrite
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031594 neuromuscular junction
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0048786 presynaptic active zone
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8yf1, PDBe:8yf1, PDBj:8yf1
PDBsum8yf1
PubMed
UniProtQ7L0J3|SV2A_HUMAN Synaptic vesicle glycoprotein 2A (Gene Name=SV2A)

[Back to BioLiP]