Structure of PDB 8y7l Chain B

Receptor sequence

>8y7lB (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]

ANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLS
GSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGK
LIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVL
ITDRHGLQEPRRVEELQNRIASCLKEHVAAVSCLSRLLGKLPELRTLCTQ
GLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

3D structure

PDB

8y7l Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy

Chain

Resolution

2.683 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1D59	B	H41 G45 P46 R119 Y122 R123 K125 H163 L166 V167	H11 G15 P16 R89 Y92 R93 K95 H133 L136 V137

External links

PDB	RCSB:8y7l, PDBe:8y7l, PDBj:8y7l
PDBsum	8y7l
PubMed
UniProt	P22736\|NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Gene Name=NR4A1)

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