Structure of PDB 8xri Chain B

Receptor sequence

>8xriB (length=772) Species: 10498 (African swine fever virus BA71V)

VDVDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPGPSFD
FCGMISLGGVIMNACKKVTNIIMVRNEQLTNNKVLQGIVQVLGLDFNCHY
KTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLIIHGFVK
RLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLVNHTVKYYKGLAAH
DTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKRELCTGVVP
LTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGMTRARRK
ILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIKAAQYYP
GSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMFPAEDSW
LLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLEDILA
LVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKRFGQYYYSY
GTYDISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEEIIDYSSSE
TIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSHLNFVKPKG
GIIEFNSYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMETAIVRYINE
SAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEELNQKALQG
CYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPFPGASVW
LEEIDAVEKAIIKGRNTQWKFH

3D structure

• PDB: 8xri The crystal structure of AsfvTopII in complex with both G-DNA and T-DNA
• Chain: B
• Resolution: 2.92 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	V473 M475 N476 K479 K480 Q498 K547 S657 R660 K661 R799 Y800 P852 S853 E854 G855 K857 S953 R1004 H1010	V60 M62 N63 K66 K67 Q78 K127 S237 R240 K241 R379 Y380 P432 S433 E434 G435 K437 S533 R584 H590
BS02	dna	B	K417 E438 G439 D440 S441 G472 V473 N496 R705 Q706 R718 Y751 H753 S761 K764 A850 N851 P852	K5 E26 G27 D28 S29 G59 V60 N76 R285 Q286 R298 Y331 H333 S341 K344 A430 N431 P432
BS03	dna	B	K727 Y744 W820 K1144	K307 Y324 W400 K724
BS04	dna	B	A730 S731 N732 N733 K811 H1099 T1100	A310 S311 N312 N313 K391 H679 T680
BS05	MG	B	E438 D539 D541	E26 D119 D121
BS06	MG	B	E593 E827	E173 E407

External links

• PDB: RCSB:8xri, PDBe:8xri, PDBj:8xri
• PDBsum: 8xri
• UniProt: Q00942|TOP2_ASFB7 DNA topoisomerase 2 (Gene Name=TOP)