Structure of PDB 8xpt Chain B

Receptor sequence
>8xptB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRN
ITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFEC
NHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEY
VGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEP
NLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGECRCGSPKCRHS
3D structure
PDB8xpt The Crystal Structure of EHMT1 from Biortus.
ChainB
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B M1136 W1138 R1197 N1200 H1201 Y1242 C1256 M131 W133 R192 N195 H196 Y237 C240
BS02 ZN B C1203 C1256 C1258 C1263 C198 C240 C242 C247
BS03 ZN B C1068 C1105 C1111 C1115 C63 C100 C106 C110
BS04 ZN B C1062 C1064 C1068 C1073 C57 C59 C63 C68
BS05 ZN B C1062 C1075 C1105 C1109 C57 C70 C100 C104
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0046974 histone H3K9 methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:8xpt, PDBe:8xpt, PDBj:8xpt
PDBsum8xpt
PubMed
UniProtQ9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)

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