Structure of PDB 8xc1 Chain B

Receptor sequence

>8xc1B (length=660) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]

NSSVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDS
SKYSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDF
GAHRKRHRIGDPHFHQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFK
TGQTTKTLSNQKLTFVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITV
PANESIYDRSVISDKTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIA
PDDSGCSTNTSRKSFNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLL
FLPIVINIIKNSSLHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDE
MCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGSHVFGTY
ECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQ
WFVRHESPSPAYTNILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGS
ICLAKERSLGSEKLKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCF
IINCIMYLMYYGCMKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTD
WTRSAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLI
NTRKTSINIF

3D structure

PDB

8xc1 Structural basis for double-stranded RNA recognition by SID1.

Chain

Resolution

2.21 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	B	H169 D171 Q174 N191 Q192 K193 K198 K301	H138 D140 Q143 N160 Q161 K162 K167 K270
BS02	rna	B	K45 K136 R172 A173 N297 K299	K14 K105 R141 A142 N266 K268
BS03	ZN	B	H540 D551 H740 H744	H424 D435 H624 H628
BS04	CLR	B	I671 W703 A704 F708 F711	I555 W587 A588 F592 F595
BS05	CLR	B	L674 G678 C679 V682 S699 F757	L558 G562 C563 V566 S583 F641
BS06	CLR	B	S313 A319 T326	S282 A288 T295

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0051033	RNA transmembrane transporter activity

	Biological Process
GO:0031047	regulatory ncRNA-mediated gene silencing
GO:0033227	dsRNA transport
GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0050658	RNA transport

	Cellular Component
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8xc1, PDBe:8xc1, PDBj:8xc1
PDBsum	8xc1
PubMed	38742627
UniProt	Q9GZC8\|SID1_CAEEL Systemic RNA interference defective protein 1 (Gene Name=sid-1)

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