Structure of PDB 8x64 Chain B

Receptor sequence
>8x64B (length=263) Species: 562,9606 [Search protein sequence]
PQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADL
IVGAVVMPMNILYLLMSKLGRPLCLFWLSMDYVASTASIFSVFILCIDRY
RSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQDKCET
DFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVKRQLNRERKAAKQLG
FIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIY
PLCNENFKKTFKR
3D structure
PDB8x64 Molecular mechanism of antihistamines recognition and regulation of the histamine H 1 receptor.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y5R B D107 Y108 W428 Y431 F432 F435 D81 Y82 W210 Y213 F214 F217
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:0043114 regulation of vascular permeability
GO:0045907 positive regulation of vasoconstriction
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:8x64, PDBe:8x64, PDBj:8x64
PDBsum8x64
PubMed38167898
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P35367|HRH1_HUMAN Histamine H1 receptor (Gene Name=HRH1)

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