Structure of PDB 8x5y Chain B

Receptor sequence
>8x5yB (length=274) Species: 562,9606 [Search protein sequence]
TTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSL
SVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVF
ILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFM
QQVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVKRQL
NRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLG
YINSTLNPLIYPLCNENFKKTFKR
3D structure
PDB8x5y Molecular mechanism of antihistamines recognition and regulation of the histamine H 1 receptor.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XB7 B N84 Y87 L88 W103 D107 Y108 S111 T112 W158 T194 A195 N198 W428 Y431 F432 F435 M451 I454 N65 Y68 L69 W84 D88 Y89 S92 T93 W139 T173 A174 N177 W221 Y224 F225 F228 M244 I247
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:0043114 regulation of vascular permeability
GO:0045907 positive regulation of vasoconstriction
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:8x5y, PDBe:8x5y, PDBj:8x5y
PDBsum8x5y
PubMed38167898
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P35367|HRH1_HUMAN Histamine H1 receptor (Gene Name=HRH1)

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