Structure of PDB 8wx7 Chain B

Receptor sequence
>8wx7B (length=512) Species: 9606 (Homo sapiens) [Search protein sequence]
TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAV
THIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHQLKEKNGDVIELKYPL
NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVR
TGDDNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETL
GTVLQLKQPLNTTRINAAEIESRVRELSKLAETTVKQGFWEEFETLQQQE
CKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINAN
IIMPEFNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG
KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTER
TVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGI
GRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRF
IYMAVQHYIETL
3D structure
PDB8wx7 Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
ChainB
Resolution2.02 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XD8 B T108 R111 F113 H114 T219 E249 E250 T253 Q257 P491 K492 Q495 T106 R109 F111 H112 T213 E241 E242 T245 Q249 P478 K479 Q482
External links
PDB RCSB:8wx7, PDBe:8wx7, PDBj:8wx7
PDBsum8wx7
PubMed39110625
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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