Structure of PDB 8wv8 Chain B

Receptor sequence

>8wv8B (length=455) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

IAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEF
DEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDALSALIERIN
YAIQKYRARRVSIDSVTSVFQQYDASSVVRRELFRLVARLKQIGATTVMT
TERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRGTSHM
KGEYPFTITDHGINIFPLRSSNVRVSSGVVRLDEMCGGGFFKDSIILATG
ATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGMDFEEM
ERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSALARGVS
NNAFRQFVIGVTGYAKQEEITGLFTNTSDQFMITDSHICVITDTIILLQY
VEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSFRNFERIISG
SPTRI

3D structure

PDB

8wv8 Structure-function relationship of KaiC around dawn

Chain

Resolution

2.93 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	B	F199 K224 L225 T228 S229 H230	F168 K193 L194 T197 S198 H199
BS02	ATP	B	K457 M458 R459 G460 S461 H463	K415 M416 R417 G418 S419 H421
BS03	ATP	B	S48 G51 K52 T53 L54 S89 F90 I239	S31 G34 K35 T36 L37 S72 F73 I208
BS04	ATP	B	T290 G291 T292 G293 K294 T295 W331 R451 I472	T252 G253 T254 G255 K256 T257 W293 R409 I430

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8wv8, PDBe:8wv8, PDBj:8wv8
PDBsum	8wv8
PubMed	38803331
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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