Structure of PDB 8wti Chain B

Receptor sequence
>8wtiB (length=305) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDML
NPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTF
3D structure
PDB8wti Discovery of alpha-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups.
ChainB
Resolution1.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X1Z B T26 H41 M49 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 D187 Q189 Q192 T26 H41 M49 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 D187 Q189 Q192
External links
PDB RCSB:8wti, PDBe:8wti, PDBj:8wti
PDBsum8wti
PubMed38101266
UniProtP0DTC1|R1A_SARS2 Replicase polyprotein 1a

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