Structure of PDB 8woq Chain B

Receptor sequence

>8woqB (length=647) Species: 9606 (Homo sapiens)

PRRDPFDAARGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNS
SSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNYQEVSRTLCPSEA
TNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRTNVAFHFTASPS
QPQYFLYKFPKDVDSVIIKVVSEMAYPCSVVSVQNIMCPVYDLDHNVEFN
GVYQSMTKKAAITLQKKDFPGEQFFVVFVIKPEDYACGGSFFIQEKENNL
QRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRFQR
KKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHP
LGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRALEPKHFGLFYAMG
IALMMEGVLSACYHVCPNYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINA
SAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYY
MYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLLLYLAFY
IIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREK
NRECILLDFFDDHDIWHFLSATALFFSFLVLLTLDDDLDVVRRDQIP

3D structure

• PDB: 8woq Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1.
• Chain: B
• Resolution: 2.85 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H563 H796 H800	H414 H613 H617
BS02	CA	B	N219 M221 P223	N185 M187 P189
BS03	CLR	B	I478 Y568	I340 Y419
BS04	SPL	B	E555 G720 W759 L807	E406 G537 W576 L624
BS05	CLR	B	G323 C324 F809 L812	G286 C287 F626 L629
BS06	CLR	B	A760 Y764	A577 Y581
BS07	CLR	B	I464 V491 L492	I326 V353 L354
BS08	CLR	B	F702 F705 R712 D713 S716 Y717 G720 F766	F519 F522 R529 D530 S533 Y534 G537 F583

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8woq, PDBe:8woq, PDBj:8woq
• PDBsum: 8woq
• PubMed: 38378654
• UniProt: Q9NXL6|SIDT1_HUMAN SID1 transmembrane family member 1 (Gene Name=SIDT1)