Structure of PDB 8wny Chain B

Receptor sequence
>8wnyB (length=456) Species: 9606 (Homo sapiens) [Search protein sequence]
LLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSL
CYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMT
FSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFT
GGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQG
SFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAM
SPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLC
FSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYV
SFINYLCYGVTILGLLLLRWRRPALHRPIKVNLLIPVAYLVFWAFLLVFS
FISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELC
FVVYPQ
3D structure
PDB8wny Cryo-EM structure of the human Asc-1 transporter complex.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DSN B I53 G55 F243 A244 S246 Y333 I12 G14 F202 A203 S205 Y292
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006865 amino acid transport
GO:0015804 neutral amino acid transport
GO:0015816 glycine transport
GO:0015825 L-serine transport
GO:0042941 D-alanine transmembrane transport
GO:0042942 D-serine transmembrane transport
GO:0055085 transmembrane transport
GO:0060094 positive regulation of synaptic transmission, glycinergic
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903444 negative regulation of brown fat cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wny, PDBe:8wny, PDBj:8wny
PDBsum8wny
PubMed38589439
UniProtQ9NS82|AAA1_HUMAN Asc-type amino acid transporter 1 (Gene Name=SLC7A10)

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