Structure of PDB 8wm9 Chain B

Receptor sequence
>8wm9B (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
SDQYIWVKRSLNCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTF
LIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEPVLIQE
GLKNTGCAIIFLLLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSS
YFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPL
FTYLVIGTLFIAAGLVALFKIRSNLQLERLMVKIGVFSVLYTVPATIVIA
CYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHT
WQKFYNRLVN
3D structure
PDB8wm9 Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.
ChainB
Resolution3.53 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 B S344 H348 W352 S149 H153 W157
BS02 Y01 B S344 S345 W352 A356 I360 S149 S150 W157 A161 I165
External links
PDB RCSB:8wm9, PDBe:8wm9, PDBj:8wm9
PDBsum8wm9
PubMed39223191
UniProtQ9ULV1|FZD4_HUMAN Frizzled-4 (Gene Name=FZD4)

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