Structure of PDB 8w8f Chain B

Receptor sequence
>8w8fB (length=1133) Species: 9823 (Sus scrofa) [Search protein sequence]
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPI
DLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVDIT
KTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYF
IINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTI
WVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDIL
EHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKR
IKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDR
DHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAI
KTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRL
NSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVG
SQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMN
TLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLL
KKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEK
EVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGV
YITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASY
TGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRE
TCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDRRYTKRD
CSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQ
KGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSA
NKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQI
FIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMER
DCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCR
NKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
3D structure
PDB8w8f Strcutures of co-transcriptional RNA capping enzymes on paused transcription complex
ChainB
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B H460 Q468 E516 Q731 R834 R841 H842 R890 K942 H1053 R1080 H425 Q433 E481 Q696 R799 R806 H807 R849 K901 H1012 R1039
BS02 dna B G1077 R1078 R1085 G1036 R1037 R1044
BS03 ZN B C1137 C1140 C1096 C1099
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w8f, PDBe:8w8f, PDBj:8w8f
PDBsum8w8f
PubMed38816438
UniProtI3LGP4

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