Structure of PDB 8w5s Chain B

Receptor sequence

>8w5sB (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]

IRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIK
DLKSELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTR
TNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSI
NHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAYSRMA
NRDLLSSVSREFSGYVESGLKTILQCALNRPAFFAERLYYAMKGAGTDDS
TLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAIVG
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3D structure

PDB

8w5s structure dissection of the membrane aggregation mechanism induced by Annexin A7 mutation

Chain

Resolution

2.1162 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	B	S396 F399 S400 E404	S209 F212 S213 E217
BS02	CA	B	G353 R356 G358 E398	G166 R169 G171 E211
BS03	CA	B	K240 L243 E248	K53 L56 E61
BS04	CA	B	M429 G431 G433 D473	M242 G244 G246 D286
BS05	CA	B	R312 T315 S316 E320	R125 T128 S129 E133
BS06	CA	B	T275 E277	T88 E90
BS07	CA	B	M270 G272 A273 G274 D314	M83 G85 A86 G87 D127
BS08	CA	B	M198 G200 E242	M11 G13 E55

External links

PDB	RCSB:8w5s, PDBe:8w5s, PDBj:8w5s
PDBsum	8w5s
PubMed
UniProt	P20073\|ANXA7_HUMAN Annexin A7 (Gene Name=ANXA7)

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