Structure of PDB 8w5c Chain B

Receptor sequence
>8w5cB (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGQVVRAEAFGMDPRPDQASTVAVKMLK
DDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLR
EFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTE
DNVMKIADFGLLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP
YPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQL
VEALDKVLLAVSE
3D structure
PDB8w5c Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
ChainB
Resolution2.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VZO B L473 V481 K503 C552 A553 A554 L619 D630 L21 V26 K47 C93 A94 A95 L147 D158
External links
PDB RCSB:8w5c, PDBe:8w5c, PDBj:8w5c
PDBsum8w5c
PubMed38348819
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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