Structure of PDB 8w3x Chain B

Receptor sequence
>8w3xB (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA
VKKLAATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYM
PNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSA
NILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDI
YSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8w3x In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).
ChainB
Resolution1.765 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AFH B E194 G195 V200 A211 Y262 Y264 M265 A315 N316 L318 S328 E33 G34 V39 A50 Y97 Y99 M100 A150 N151 L153 S163
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8w3x, PDBe:8w3x, PDBj:8w3x
PDBsum8w3x
PubMed38628800
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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