Structure of PDB 8w0u Chain B

Receptor sequence

>8w0uB (length=397) Species: 9606 (Homo sapiens) [Search protein sequence]

EERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA
GEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGP
GFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQ
GIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISL
FLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFY
YIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQH
KLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYD
CVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFD

3D structure

PDB

8w0u Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases.

Chain

Resolution

2.8 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	B	R317 F320 L327 Q385 L386 G388 G389	R285 F288 L295 Q353 L354 G356 G357
BS02	FAD	B	I170 M172 T173 G178 S179 F203 I204 S205 V407 Y411 T414 I417	I138 M140 T141 G146 S147 F171 I172 S173 V375 Y379 T382 I385
BS03	CAA	B	I136 M172 S179 Q182 H228 Y282 M285 E291 R292 Y411 G412	I104 M140 S147 Q150 H196 Y250 M253 E259 R260 Y379 G380

Gene Ontology

	Molecular Function
GO:0000062	fatty-acyl-CoA binding
GO:0004466	long-chain fatty acyl-CoA dehydrogenase activity
GO:0005515	protein binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0001659	temperature homeostasis
GO:0006631	fatty acid metabolic process
GO:0019254	carnitine metabolic process, CoA-linked
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042413	carnitine catabolic process
GO:0042758	long-chain fatty acid catabolic process
GO:0044242	cellular lipid catabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0046322	negative regulation of fatty acid oxidation
GO:0090181	regulation of cholesterol metabolic process
GO:0120162	positive regulation of cold-induced thermogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0031966	mitochondrial membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8w0u, PDBe:8w0u, PDBj:8w0u
PDBsum	8w0u
PubMed	38839792
UniProt	P28330\|ACADL_HUMAN Long-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADL)

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