Structure of PDB 8vzp Chain B

Receptor sequence
>8vzpB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAK
RVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR
NQGKCGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSS
TLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYNVVPSYDLLLEMLDA
3D structure
PDB8vzp Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu.
ChainB
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AHW B T347 A350 E353 W383 L384 L387 G521 L525 V533 T35 A38 E41 W71 L72 L75 G207 L211 V214
External links
PDB RCSB:8vzp, PDBe:8vzp, PDBj:8vzp
PDBsum8vzp
PubMed38830107
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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