Structure of PDB 8vz1 Chain B

Receptor sequence

>8vz1B (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADRELVHMINWAKR
VPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QGKMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSL
EEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMNVVPSYDLLLEMLDA

3D structure

PDB

8vz1 Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu.

Chain

Resolution

1.82 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AHS	B	T347 E353 L387 M388 M421 I424 G521 H524	T34 E40 L74 M75 M104 I107 G202 H205

External links

PDB	RCSB:8vz1, PDBe:8vz1, PDBj:8vz1
PDBsum	8vz1
PubMed	38830107
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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