Structure of PDB 8vug Chain B

Receptor sequence

>8vugB (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]

GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILW
ELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTAL
DFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEE
NELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF
IRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRA
LQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGS
KAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKF
LEH

3D structure

PDB

8vug Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.05 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	A1AD1	B	Y42 Y45	Y4 Y7
BS02	HEM	B	F72 H76 Y79 L132 F140 S151 G152 F153 F158 R159 Y175 W324 H328 M331 V332 M335 L336 Y350 L351	F34 H38 Y41 L94 F102 S113 G114 F115 F120 R121 Y137 W286 H290 M293 V294 M297 L298 Y312 L313
BS03	ZIQ	B	R103 E105 W208 R211 T212 P213 F304 P307	R65 E67 W170 R173 T174 P175 F266 P269
BS04	A1AD1	B	F72 H76 R144 A150 S151 G152 L336 G341 T342	F34 H38 R106 A112 S113 G114 L298 G303 T304

External links

PDB	RCSB:8vug, PDBe:8vug, PDBj:8vug
PDBsum	8vug
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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