Structure of PDB 8vsu Chain B

Receptor sequence
>8vsuB (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
SSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSN
EMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLI
CTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKV
YLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAK
SDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIHPYH
RTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLR
PVTPIT
3D structure
PDB8vsu High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.
ChainB
Resolution2.86 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B G78 F79 M83 T98 R100 M150 D157 H200 L202 R215 G19 F20 M24 T39 R41 M91 D98 H141 L143 R156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019900 kinase binding
GO:0030295 protein kinase activator activity
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0032147 activation of protein kinase activity
GO:0070314 G1 to G0 transition
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0140535 intracellular protein-containing complex
GO:1902554 serine/threonine protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vsu, PDBe:8vsu, PDBj:8vsu
PDBsum8vsu
PubMed38944401
UniProtQ7RTN6|STRAA_HUMAN STE20-related kinase adapter protein alpha (Gene Name=STRADA)

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