Structure of PDB 8vs6 Chain B

Receptor sequence
>8vs6B (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
INTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNI
EKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSD
YNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQA
AVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNV
YVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPGTIA
GEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRK
PGMEGCRNVTSNDEVLFNVTVTMKKCDNYAIIKPIGFNETAKIHIHRNC
3D structure
PDB8vs6 Dynamic allostery drives autocrine and paracrine TGF-beta signaling
ChainB
Resolution2.73 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B A115 S116 C169 Y172 L174 G206 N207 I208 T210 E212 A44 S45 C98 Y101 L103 G135 N136 I137 T139 E141
BS02 CA B D151 N207 D209 T210 P211 E212 D80 N136 D138 T139 P140 E141
BS03 MG B S114 S116 E212 S43 S45 E141
External links
PDB RCSB:8vs6, PDBe:8vs6, PDBj:8vs6
PDBsum8vs6
PubMed
UniProtP26012|ITB8_HUMAN Integrin beta-8 (Gene Name=ITGB8)

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