Structure of PDB 8vlx Chain B

Receptor sequence
>8vlxB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
AEAGEQFGQLGRELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEA
ARLFLRQERDARQRLVCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAA
LCLELAAALRDLGQPAAAAGHFQRAAQLQLPQLPLAALQALGEAASCQLL
ARDYTGALAVFTRMQRLAREHGSPAALGAFSDVLVRCEVSRVLLLLLLQP
PPAKLLPEHAQTLEKYSSSGQLPEELFLLLQSLVMATHEKDTEAIKSLQV
EMWPLLTAEQNHLLHLVLQETISPSGQGV
3D structure
PDB8vlx Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1ACS B R213 Y215 S385 R152 Y154 S275
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0099518 vesicle cytoskeletal trafficking
GO:1901799 negative regulation of proteasomal protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0016604 nuclear body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vlx, PDBe:8vlx, PDBj:8vlx
PDBsum8vlx
PubMed
UniProtP23610|HAP40_HUMAN 40-kDa huntingtin-associated protein (Gene Name=F8A1)

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