Structure of PDB 8vlu Chain B

Receptor sequence
>8vluB (length=546) Species: 9606 (Homo sapiens) [Search protein sequence]
LKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPSA
AAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIEIACDL
AVNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAIPPR
LRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFVFIM
GSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLS
WDKVRIPGVLQRLGVTYFVVAVLELLFAKPVPEHCASERSCLSLRDITSS
WPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAA
GYIDRLLLGDDHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQA
GKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVF
ENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRKKIFWKI
3D structure
PDB8vlu Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome
ChainB
Resolution3.12 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B R267 L268 D272 R275 M282 F310 F313 S320 L323 S324 K341 R345 V376 L380 S607 I608 Y611 K662 R150 L151 D155 R158 M165 F193 F196 S203 L206 S207 K224 R228 V259 L263 S490 I491 Y494 K545
Gene Ontology
Molecular Function
GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0007041 lysosomal transport
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0051259 protein complex oligomerization
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035579 specific granule membrane
GO:0043202 lysosomal lumen
GO:0070821 tertiary granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vlu, PDBe:8vlu, PDBj:8vlu
PDBsum8vlu
PubMed
UniProtQ68CP4|HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (Gene Name=HGSNAT)

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