Structure of PDB 8vli Chain B

Receptor sequence
>8vliB (length=543) Species: 9606 (Homo sapiens) [Search protein sequence]
AELKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKP
SAAAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIIACD
LAVNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAIAL
PPRLRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFV
FIMGSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLG
PLSWDKVRIPGVLQRLGVTYFVVAVLELLFAKPVPESCLSLRDITSSWPQ
WLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYI
DRLLLGDDHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKI
LLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWSLSY
VTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENY
FPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRKKIFWKI
3D structure
PDB8vli Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome
ChainB
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B R267 L268 R275 F310 F313 S320 S324 K341 R345 V376 L380 S607 Y611 R153 L154 R161 F196 F199 S206 S210 K227 R231 V262 L266 S487 Y491
BS02 A1AC0 B N286 H297 R372 E499 K563 E615 E618 N172 H183 R258 E379 K443 E495 E498
Gene Ontology
Molecular Function
GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0007041 lysosomal transport
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0051259 protein complex oligomerization
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035579 specific granule membrane
GO:0043202 lysosomal lumen
GO:0070821 tertiary granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vli, PDBe:8vli, PDBj:8vli
PDBsum8vli
PubMed
UniProtQ68CP4|HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (Gene Name=HGSNAT)

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