Structure of PDB 8vkz Chain B

Receptor sequence
>8vkzB (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKW
AKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDL
IINEPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKS
QELFDEIRMTYIKELGKAIVKQNWQRFYQLTKLLDSMHEVVENLLNYCFQ
TFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB8vkz Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties
ChainB
Resolution2.133 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I572 V575 K579 R585 M593 Q597 M752 E755 I45 V48 K52 R58 M66 Q70 M214 E217
BS02 A1ACE B M560 L563 N564 Q570 M601 M604 F623 E631 M639 C643 M646 Y735 C736 T739 M33 L36 N37 Q43 M74 M77 F96 E104 M107 C111 M114 Y197 C198 T201
External links
PDB RCSB:8vkz, PDBe:8vkz, PDBj:8vkz
PDBsum8vkz
PubMed38516584
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]