Structure of PDB 8vhq Chain B

Receptor sequence
>8vhqB (length=734) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QNLLVTKRDGSTERINLDKIHRVLDAAAEGLHNVSISQVELRSHIQFYDG
IKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPAL
YDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLE
GKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVST
FKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRA
GIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAA
TLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGED
ITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLM
MQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDV
NDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPA
AKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLL
KASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEAL
RESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGIL
RQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPS
RFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRD
3D structure
PDB8vhq How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
ChainB
Resolution3.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTP B S249 C292 S247 C290
BS02 DTP B V7 K9 R10 E15 I17 N18 I22 T55 H59 V5 K7 R8 E13 I15 N16 I20 T53 H57
BS03 ATP B K9 K21 H59 F87 F97 K7 K19 H57 F85 F95
BS04 DTP B D232 S233 L234 R262 I268 R269 H275 D230 S231 L232 R260 I266 R267 H273
External links
PDB RCSB:8vhq, PDBe:8vhq, PDBj:8vhq
PDBsum8vhq
PubMed39164005
UniProtP00452|RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha (Gene Name=nrdA)

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