Structure of PDB 8v9q Chain B

Receptor sequence
>8v9qB (length=449) Species: 10090 (Mus musculus) [Search protein sequence]
GPGEMPVVIPKEKMKEMFKINQASEMIALNRSLPDVRLEGCKTKVYPDNL
PTTSVVIFHNESTLRTVHSVINRSPRHMIEEIVDASERDFLKRPSYVKKL
KVPVVIREQRSGLIRARLSRGQVTFLDAHCETAGWLEPLLARIKHDRRTV
CPIIDVISDDTFEYMAGSDMTYGFNWKLNFRWYPVPQREMDRRKGDRTLP
VRTPTMALFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIV
TCSHVGHVFRKATPYQIINKNNRRLAEVWMDEFKNFFYIISVTKVDYGDI
SSRLGLRRKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNM
AKENEKVGIFNCHGMGNQVFSYTANKEIRTDDLCLDVSKLNPVTMLKCHH
LKNQLWEDPVKLTLQHVNSNQCLDKAQVPSIRDCTGSRSQQWLLRNVTL
3D structure
PDB8v9q An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase.
ChainB
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V240 F265 R266 W267 F346 R347 E450 N503 V156 F180 R181 W182 F259 R260 E353 N403
BS02 UDP B H125 D156 R186 S187 H211 H344 R347 H59 D84 R110 S111 H129 H257 R260
BS03 MN B H211 H344 R347 H129 H257 R260
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:8v9q, PDBe:8v9q, PDBj:8v9q
PDBsum8v9q
PubMed38416819
UniProtO08912|GALT1_MOUSE Polypeptide N-acetylgalactosaminyltransferase 1 (Gene Name=Galnt1)

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