Structure of PDB 8v9i Chain B

Receptor sequence

>8v9iB (length=576) Species: 1299 (Deinococcus radiodurans) [Search protein sequence]

SDTPLLDQIHGPKDLKRLSREQLPALTEELRGEIVRVCSRGGLHLASSLG
AVDIITALHYVLDSPRDRILFDVGHQAYAHKILTGRRDQMADIKKEGGIS
GFTKVSESEHDAITVGHASTSLANALGMALARDAQGKDFHVAAVIGDGSL
TGGMALAALNTIGDMGRKMLIVLNDNEMSISENVGAMNKFMRGSVNPFAA
MGVRYVGPVDGHNVQELVWLLERLVDLDGPTILHIVTTKGKGLSYAEADP
IYWHGPAKFDPATGEYVPSSAYSWSAAFGEAVTEWAKTDPRTFVVTPAMR
EGSGLVEFSRVHPHRYLDVGIAEEVAVTTAAGMALQGMRPVVAIYSTFLQ
RAYDQVLHDVAIEHLNVTFCIDRAGIVGADGATHNGVFDLSFLRSIPGVR
IGLPKDAAELRGMLKYAQTHDGPFAIRYPRGNTAQVPAGTWPDLKWGEWE
RLKGGDDVVILAGGKALDYALKAAEDLPGVGVVNARFVKPLDEEMLREVG
GRARALITVEDNTVVGGFGGAVLEALNSMNLHPTVRVLGIPDEFQEHATA
ESVHARAGIDAPAIRTVLAELGVDVP

3D structure

PDB

8v9i Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog.

Chain

Resolution

1.981 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AAN	B	G49 L50 H51 S54 H82 H124 A125 G153 D154 G155 S156 N183 M185 S186 I187 K289 H304 G305 M349 I371 E373 F398 R423 D430 H434 R480	G42 L43 H44 S47 H75 H117 A118 G146 D147 G148 S149 N176 M178 S179 I180 K239 H254 G255 M299 I321 E323 F348 R373 D380 H384 R430
BS02	MG	B	D154 N183 M185	D147 N176 M178

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0008661	1-deoxy-D-xylulose-5-phosphate synthase activity
GO:0016740	transferase activity
GO:0030976	thiamine pyrophosphate binding
GO:0046872	metal ion binding

	Biological Process
GO:0008299	isoprenoid biosynthetic process
GO:0009228	thiamine biosynthetic process
GO:0016114	terpenoid biosynthetic process
GO:0019288	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0052865	1-deoxy-D-xylulose 5-phosphate biosynthetic process

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8v9i, PDBe:8v9i, PDBj:8v9i
PDBsum	8v9i
PubMed	38513073
UniProt	Q9RUB5\|DXS_DEIRA 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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