Structure of PDB 8v4x Chain B

Receptor sequence
>8v4xB (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
PLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLT
EYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSE
NCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIV
FGYATCQGAEAFEIQHLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKC
HLTKGKQALEIRSSLSEKRALTDPIQGNLQWAKAHELPESMCLKFDCGVQ
IQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKG
TPEETGSYKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVN
VGKPLIAKLD
3D structure
PDB8v4x Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.
ChainB
Resolution2.486 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B D365 A413 G414 H415 D462 C464 E497 A498 F499 E500 I501 Q502 H503 D28 A76 G77 H78 D125 C127 E160 A161 F162 E163 I164 Q165 H166
BS02 A1AAB B K379 V381 E390 N393 A394 E397 F398 L401 Q579 W580 Q676 I712 K42 V44 E53 N56 A57 E60 F61 L64 Q230 W231 Q320 I356
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8v4x, PDBe:8v4x, PDBj:8v4x
PDBsum8v4x
PubMed38507740
UniProtQ9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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