Structure of PDB 8v42 Chain B

Receptor sequence
>8v42B (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
FAVGEIITDMAAAAWKVGLPICIYLADMNSSDAPCVVKVEPGPLFTELKF
YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKYRFMIMDRFGSDLQK
IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP
DQVYLVDYGLAYRYCPEGVHKAYAADPKRCHDGTIEFTSIDAHNGVAPSR
RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCF
NAPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDL
3D structure
PDB8v42 Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1 delta / epsilon.
ChainB
Resolution2.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YD9 B I43 V69 K71 M131 D132 R133 F134 G135 L184 V196 I21 V36 K38 M91 D92 R93 F94 G95 L144 V156
External links
PDB RCSB:8v42, PDBe:8v42, PDBj:8v42
PDBsum8v42
PubMed38780468
UniProtQ99986|VRK1_HUMAN Serine/threonine-protein kinase VRK1 (Gene Name=VRK1)

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