Structure of PDB 8v2f Chain B

Receptor sequence
>8v2fB (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA
VKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLV
YVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRD
IKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR
GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIE
DYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8v2f Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
ChainB
Resolution2.09 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YJU B M192 V200 A211 Y262 V263 Y264 M265 P266 G268 L318 M31 V39 A50 Y101 V102 Y103 M104 P105 G107 L157
External links
PDB RCSB:8v2f, PDBe:8v2f, PDBj:8v2f
PDBsum8v2f
PubMed38920289
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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