Structure of PDB 8v0c Chain B

Receptor sequence

>8v0cB (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]

GNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDW
LVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFG
THHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTH
KSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESK
WLCSEFKESMLTLGKESSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQ
TAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSA
NLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGSQE
PMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP

3D structure

PDB

8v0c Structures of TDP1 complexed with inhibitors

Chain

Resolution

1.62 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YE3	B	Y204 C205 H263 K265 N283 P461 H493 W590	Y44 C45 H103 K105 N123 P296 H328 W425

External links

PDB	RCSB:8v0c, PDBe:8v0c, PDBj:8v0c
PDBsum	8v0c
PubMed
UniProt	Q9NUW8\|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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