Structure of PDB 8uzz Chain B

Receptor sequence

>8uzzB (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]

NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWL
VKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGT
HHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHK
SGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGR
FQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKW
LCSEFKESMLTLGKESSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQT
AEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSAN
LSKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGSQEP
MATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS

3D structure

PDB

8uzz Structureal analysis of TDP1 in complex with inhbitors

Chain

Resolution

1.93 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YA5	B	Y204 H263 K265 N283 P461 H493 W590	Y43 H102 K104 N122 P295 H327 W424

External links

PDB	RCSB:8uzz, PDBe:8uzz, PDBj:8uzz
PDBsum	8uzz
PubMed
UniProt	Q9NUW8\|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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