Structure of PDB 8uy1 Chain B

Receptor sequence
>8uy1B (length=575) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
MHIRDMLAEAERTGEPSFSFQYFPPKTAQGVQNLYDRMERMYNYGPKFID
ITWGAGVAELTCEMVVQAQAYLGLETCMHLTCTDMGVERINDALRKAYKA
GCTNILKEKWEAAKDGFRYAKDLVAHIRKEYGDHFDIGVADEDLLLDHLK
EKVDMGAGFIVTQMFYDVDNFLRWVKKVRERGISVPIVPGIMPIATYASF
LRRANHMKCKIPEEWMAKLEPVKNDDVAVREIGKTLVADMCRKILDAGIR
HLHFYTMNLAQATRMVLEELNWLPSPDRPLKHALPWKQSLGFGRRGEDVR
PIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGVGLTGSNEQ
NRERWGEPKCIRDIANLFIRYMRKEIDYLPWSEAPVADEADLIKDELIDL
NRRGLITVNSQPAVNGAKSNHPVHGWGPSNGYVYQKAYLEFFVSPELYPE
IKRRIESHPDLTYHAVTKSGNLETNAQSDGPNAVTWGVFPGKEIFQPTIV
ERISFLAWKDEAYHLGMEWARCYDAGSPSRVLLEEMMNTWWLVNIVNNDF
HQGNTLFEILKGLEVTDLDKVPETQ
3D structure
PDB8uy1 Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.
ChainB
Resolution3.49 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B T52 W53 H81 T83 Y130 A131 K132 H169 K173 Q184 T52 W53 H79 T81 Y119 A120 K121 H148 K152 Q163
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
Biological Process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uy1, PDBe:8uy1, PDBj:8uy1
PDBsum8uy1
PubMed38886362
UniProtG0S5U9

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