Structure of PDB 8uw1 Chain B

Receptor sequence

>8uw1B (length=79) Species: 8355 (Xenopus laevis) [Search protein sequence]

DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT
EHAKRKTVTAMDVVYALKRQGRTLYGFGG

3D structure

PDB

8uw1 Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.

Chain

Resolution

2.88 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	R35 R45 I46 G48 K79 T80	R12 R22 I23 G25 K56 T57
BS02	dna	B	P32 R36 R45	P9 R13 R22

External links

PDB	RCSB:8uw1, PDBe:8uw1, PDBj:8uw1
PDBsum	8uw1
PubMed	39196936
UniProt	A0A8J1LTD2

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